D.M.S.O Bladder Instillations

Dimethyl Sulfoxide (DMSO) is a solution used for the symptomatic relief for patients with interstitial cystitis.

The bladder instillations of D.M.S.O. 50% in 50 % aqueous solution are given weekly for 6 weeks if tolerated. Symptoms are reassessed at the conclusion of the course of treatment. The instillations may be continued 2nd weekly or monthly as needed to control the symptoms of interstitial cystitis. Your doctor will determine if this is necessary.

Points to note

  • You will be admitted into the day care unit/ambulatory care unit. The date and time of commencement of treatment will be arranged following your initial appointment with the specialist nurse. At this initial appointment, the procedure is discussed including the tests required, precautions required at home and a consent form is obtained.
  • Following your admission, DMSO will be instilled into your bladder via a tube (nelaton catheter).
  • You will be instructed to retain the solution for 15 minutes. After this time, the medication is expelled by spontaneous voiding.
  • DMSO may alter the effectiveness of other medications that you are presently receiving. Please inform your doctor of what medications you are currently taking.
  • You may notice a garlic like taste in your mouth shortly after instillation of DMSO. This taste may last several hours. An odour on the breath and skin may be present for up to 72 hours.
  • You may experience moderately to severe discomfort on administration. Usually, this becomes less of a problem with repeated doses.
  • You must inform your doctor if you are pregnant or breast feeding.